WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: .05, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=22; E=7.65; R=2.88; rawP=1.11e-05; adjP=0.0007
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166311 NA SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 6609 ENSG00000166311
2  ENSG00000173085 NA COQ2 coenzyme Q2 homolog, prenyltransferase (yeast) 27235 ENSG00000173085
3  ENSG00000137944 NA CCBL2 cysteine conjugate-beta lyase 2 56267 ENSG00000137944
4  ENSG00000101464 NA PIGU phosphatidylinositol glycan anchor biosynthesis, class U 128869 ENSG00000101464
5  ENSG00000067225 NA PKM pyruvate kinase, muscle 5315 ENSG00000067225
6  ENSG00000116096 NA SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 6697 ENSG00000116096
7  ENSG00000158467 NA AHCYL2 adenosylhomocysteinase-like 2 23382 ENSG00000158467
8  ENSG00000160688 NA FLAD1 FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) 80308 ENSG00000160688
9  ENSG00000100605 NA ITPK1 inositol-tetrakisphosphate 1-kinase 3705 ENSG00000100605
10  ENSG00000106992 NA AK1 adenylate kinase 1 203 ENSG00000106992
11  ENSG00000156136 NA DCK deoxycytidine kinase 1633 ENSG00000156136
12  ENSG00000157881 NA PANK4 pantothenate kinase 4 55229 ENSG00000157881
13  ENSG00000068120 NA COASY CoA synthase 80347 ENSG00000068120
14  ENSG00000174915 NA PTDSS2 phosphatidylserine synthase 2 81490 ENSG00000174915
15  ENSG00000114378 NA HYAL1 hyaluronoglucosaminidase 1 3373 ENSG00000114378
16  ENSG00000120053 NA GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 2805 ENSG00000120053
17  ENSG00000163281 NA GNPDA2 glucosamine-6-phosphate deaminase 2 132789 ENSG00000163281
18  ENSG00000256269 NA HMBS hydroxymethylbilane synthase 3145 ENSG00000256269
19  ENSG00000185000 NA DGAT1 diacylglycerol O-acyltransferase 1 8694 ENSG00000185000
20  ENSG00000172893 NA DHCR7 7-dehydrocholesterol reductase 1717 ENSG00000172893
21  ENSG00000131100 NA ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 529 ENSG00000131100
22  ENSG00000111669 NA TPI1 triosephosphate isomerase 1 7167 ENSG00000111669


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=10; E=2.21; R=4.53; rawP=8.65e-05; adjP=0.0018
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105229 NA PIAS4 protein inhibitor of activated STAT, 4 51588 ENSG00000105229
2  ENSG00000096384 NA HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 3326 ENSG00000096384
3  ENSG00000138798 NA EGF epidermal growth factor 1950 ENSG00000138798
4  ENSG00000196730 NA DAPK1 death-associated protein kinase 1 1612 ENSG00000196730
5  ENSG00000107404 NA DVL1 dishevelled, dsh homolog 1 (Drosophila) 1855 ENSG00000107404
6  ENSG00000064012 NA CASP8 caspase 8, apoptosis-related cysteine peptidase 841 ENSG00000064012
7  ENSG00000112715 NA VEGFA vascular endothelial growth factor A 7422 ENSG00000112715
8  ENSG00000157404 NA KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 3815 ENSG00000157404
9  ENSG00000159692 NA CTBP1 C-terminal binding protein 1 1487 ENSG00000159692
10  ENSG00000126934 NA MAP2K2 mitogen-activated protein kinase kinase 2 5605 ENSG00000126934


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=8; E=1.36; R=5.88; rawP=7.46e-05; adjP=0.0018
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000138798 NA EGF epidermal growth factor 1950 ENSG00000138798
2  ENSG00000088280 NA ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 55616 ENSG00000088280
3  ENSG00000119541 NA VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 9525 ENSG00000119541
4  ENSG00000063245 NA EPN1 epsin 1 29924 ENSG00000063245
5  ENSG00000159210 NA SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 11267 ENSG00000159210
6  ENSG00000157404 NA KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 3815 ENSG00000157404
7  ENSG00000204389 NA HSPA1A heat shock 70kDa protein 1A 3303 ENSG00000204389
8  ENSG00000204388 NA HSPA1B heat shock 70kDa protein 1B 3304 ENSG00000204388


Database:KEGG pathway       Name:Bladder cancer       ID:05219
C=42; O=4; E=0.28; R=14.07; rawP=0.0002; adjP=0.0031
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000112715 NA VEGFA vascular endothelial growth factor A 7422 ENSG00000112715
2  ENSG00000126934 NA MAP2K2 mitogen-activated protein kinase kinase 2 5605 ENSG00000126934
3  ENSG00000138798 NA EGF epidermal growth factor 1950 ENSG00000138798
4  ENSG00000196730 NA DAPK1 death-associated protein kinase 1 1612 ENSG00000196730


Database:KEGG pathway       Name:Prion diseases       ID:05020
C=35; O=3; E=0.24; R=12.66; rawP=0.0017; adjP=0.0183
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000176919 NA C8G complement component 8, gamma polypeptide 733 ENSG00000176919
2  ENSG00000126934 NA MAP2K2 mitogen-activated protein kinase kinase 2 5605 ENSG00000126934
3  ENSG00000204389 NA HSPA1A heat shock 70kDa protein 1A 3303 ENSG00000204389


Database:KEGG pathway       Name:Antigen processing and presentation       ID:04612
C=76; O=4; E=0.51; R=7.77; rawP=0.0018; adjP=0.0183
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000241106 NA HLA-DOB major histocompatibility complex, class II, DO beta 3112 ENSG00000241106
2  ENSG00000096384 NA HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 3326 ENSG00000096384
3  ENSG00000204389 NA HSPA1A heat shock 70kDa protein 1A 3303 ENSG00000204389
4  ENSG00000204388 NA HSPA1B heat shock 70kDa protein 1B 3304 ENSG00000204388


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=5; E=0.91; R=5.47; rawP=0.0023; adjP=0.0200
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105229 NA PIAS4 protein inhibitor of activated STAT, 4 51588 ENSG00000105229
2  ENSG00000130985 NA UBA1 ubiquitin-like modifier activating enzyme 1 7317 ENSG00000130985
3  ENSG00000107341 NA UBE2R2 ubiquitin-conjugating enzyme E2R 2 54926 ENSG00000107341
4  ENSG00000114125 NA RNF7 ring finger protein 7 9616 ENSG00000114125
5  ENSG00000185651 NA UBE2L3 ubiquitin-conjugating enzyme E2L 3 7332 ENSG00000185651


Database:KEGG pathway       Name:Notch signaling pathway       ID:04330
C=47; O=3; E=0.32; R=9.43; rawP=0.0040; adjP=0.0305
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107404 NA DVL1 dishevelled, dsh homolog 1 (Drosophila) 1855 ENSG00000107404
2  ENSG00000117362 NA APH1A anterior pharynx defective 1 homolog A (C. elegans) 51107 ENSG00000117362
3  ENSG00000159692 NA CTBP1 C-terminal binding protein 1 1487 ENSG00000159692


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=5; E=1.12; R=4.48; rawP=0.0055; adjP=0.0322
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000133265 NA HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 23640 ENSG00000133265
2  ENSG00000096384 NA HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 3326 ENSG00000096384
3  ENSG00000204389 NA HSPA1A heat shock 70kDa protein 1A 3303 ENSG00000204389
4  ENSG00000204388 NA HSPA1B heat shock 70kDa protein 1B 3304 ENSG00000204388
5  ENSG00000138073 NA PREB prolactin regulatory element binding 10113 ENSG00000138073


Database:KEGG pathway       Name:Selenocompound metabolism       ID:00450
C=17; O=2; E=0.12; R=17.38; rawP=0.0058; adjP=0.0322
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000137944 NA CCBL2 cysteine conjugate-beta lyase 2 56267 ENSG00000137944
2  ENSG00000197763 NA TXNRD3 thioredoxin reductase 3 114112 ENSG00000197763


Database:KEGG pathway       Name:Pantothenate and CoA biosynthesis       ID:00770
C=16; O=2; E=0.11; R=18.46; rawP=0.0051; adjP=0.0322
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000157881 NA PANK4 pantothenate kinase 4 55229 ENSG00000157881
2  ENSG00000068120 NA COASY CoA synthase 80347 ENSG00000068120


Database:KEGG pathway       Name:NOD-like receptor signaling pathway       ID:04621
C=58; O=3; E=0.39; R=7.64; rawP=0.0072; adjP=0.0366
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000165416 NA SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 10910 ENSG00000165416
2  ENSG00000064012 NA CASP8 caspase 8, apoptosis-related cysteine peptidase 841 ENSG00000064012
3  ENSG00000096384 NA HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 3326 ENSG00000096384




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).